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PK/PD Modeling & Dose Simulation
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PK/PD Modeling & Dose Simulation

Rational Dose Selection & Translational Modelling

We develop pharmacokinetic and pharmacodynamic models to connect dose, exposure, target engagement, efficacy, and safety. From compartmental PK fitting to population variability modelling and Monte Carlo simulations, our analyses support rational dose selection, study design, and clear client-facing reports for regulatory and strategic decisions.

Key Features

  • Compartmental PK Modelling

    One-, two-, and multi-compartment models fitted to oral, IV, and multi-route dosing data characterise absorption, distribution, and elimination.

  • Population Variability & Mixed-Effects Concepts

    Nonlinear mixed-effects modelling principles capture between-subject variability and covariate relationships across patient populations.

  • Exposure–Response & PD Modelling

    Emax, indirect response, and disease-progression models link drug exposure to pharmacodynamic endpoints and efficacy readouts.

  • Monte Carlo Simulation & Uncertainty Analysis

    Dose simulations propagate parameter uncertainty to predict clinical outcomes and inform dose justification with quantified confidence.